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Ornithine is a nonprotein amino acid. It is used in the body in the biosynthesis of L-arginine, L-proline, and polyamines. Ornithine is used as a nutritional supplement principally for its putative anabolic activity. A derivative of ornithine called ornithine alpha-ketoglutarate or OKG may under certain conditions have immunomodulatory and anticatabolic and/or anabolic actions.

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