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Leucine is an essential amino acid and is not synthesized in the body. Chemically it is alpha-aminoisocaproic acid. The microorganisms may synthesize this amino acid. In microorganisms it is synthesized from alpha-ketoisovaleric aicd and acetyl CoA.

Leucine can be broken down into simpler compounds by the enzymes of the body. Leucine contributes to the structure of proteins into which it has been incorporated by the tendency of its side chain to participate in hydrophobic interactions.

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