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Pregnenolone is the precursor (building-block) for all other steroid hormones. It is converted directly into DHEA and/or progesterone. DHEA converts to testosterone and estrogens; progesterone converts to estrogens, cortisol, and aldosterone. It is this succession of conversions that makes human life possible. Without pregnenolone, there can be no human steroid hormone production.

Made from cholesterol, pregnenolone is a natural steroid hormone produced primarily in the adrenal glands, but in smaller amounts by many other organs and tissues of the human body, including liver, brain, skin, gonads, and even the retina of the eye.

Pregnenolone is reported to have several benefits, such as treating depression, arthritis, multiple sclerosis, and seizures. This hormone is also claimed to be beneficial for slowing down the aging process, enhancing memory, increasing energy, stimulating the immune system, and improving the body's response to stress. However, there is insufficient scientific evidence to support the effectiveness of these pregnenolone benefits.

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