Nitric oxide supplementation has increasingly become one of the most saturated muscle-building categories in recent years. However, most people don't know how it really works. The amino acid L-arginine is first delivered to the endothelial cells. By then nitric oxide is formed through the enzyme nitric oxide synthase (NOS), making L-arginine a primary precursor of nitric oxide. High levels of NO results in vasodilation, which is the widening of blood vessels that help induce intense blood volume, also known as “the pump” in muscle-building terms. Bodybuilders are all about the pump. However, the mechanisms behind L-arginine supplementation is actually more complicated than immediate promises of bulking muscles.

This brings us to the “arginine paradox”. There exists an inexplicable difference between in vitro and in vivo studies. In the first place, L-arginine has multiple uses other than NO production. According to the PDR for Nutritional Supplements, in vitro studies have shown that NOS is largely saturated with its L-arginine substrate given that it's happening within normal physiological conditions. This implies that L-arginine is not rate limiting for the NOS enzyme, which then indicates that supplementing copious amounts of L-arginine does not necessarily translate to increased NO production. In contrast, in vivo studies show that under particular physiological conditions, L-arginine supplementation can actually enhance vasodilation and NO production, possibly attributed to the NOS inhibitors produced during the process. Apart from this, most NO formulas fail to recognize that L-arginine is easily disrupted by arginase before it even reaches the endothelial cells. Usually they incorporate L-arginine alpha-keto-glutarate (AAKG), a precursor of L-arginine which has the ability to bypass the arginase enzyme. The incorporation of an intermediary compound may sabotage the full effects of L-arginine for optimum NO synthesis. This is where Hi-Tech Pharmaceuticals N.O. Overload Pounding Punch 310g comes in.

Hi-Tech Pharmaceuticals N.O. Overload Pounding Punch 310g features a “straight up the middle” approach which allows high levels of L-arginine, with special arginase inhibitors, to effectively bond with arginase, resulting to optimum L-arginine delivery and NO production. This formula is also packed with 9 muscle cell volumizing compounds, 5 NO drivers with Micro-Rx and Extend-Rx, 6 energy boosters, and 4 amino acid recovery compounds. Hi-Tech Pharmaceuticals N.O. Overload Pounding Punch 310g is a revolutionary pre-workout formula that provides over 30 compounds, with arginase inhibitors, to create the most compelling muscle-building environment possible.